The
NEW C-Pace EP from Harvard Appartus is a multi-channel stimulator designed for
the chronic stimulation of bulk quantities of cells in culture incubators. This
pacer emits bipolar stimuli, greatly reducing electrolysis at the electrodes.
Features
include:
Allows treatment of cells in their native environmental
conditions
Prevents de-differentiation of adult cardiomyocytes
Encourages pre-commitment of Stem Cells toward certain
muscle phenotypes
Ideal for cardiac tissue engineering
In
addition to standard pacing protocols, the EP has flexible pacing protocols for
arrhythmia, exercise, and irregular pacing. Advanced TTL triggering allows
switching to the next programmed pulse train. Functionality can be generalized
(e.g. acute pacing) using the Gate and Aux outputs.
The
primary benefit of this system is that it allows the researcher to treat the
cells in a manner consistent with their native environment. Like using proper
maintenance media and incubation, chronic culture pacing will help induce
and/or maintain phenotype over time, a key necessity for utilization in cardiac
tissue engineering.